5-Hydroxymethylcytosine in E-box motifs ACAT|GTG and ACAC|GTG increases DNA-binding of the B-HLH transcription factor TCF4
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چکیده
منابع مشابه
Global MYCN Transcription Factor Binding Analysis in Neuroblastoma Reveals Association with Distinct E-Box Motifs and Regions of DNA Hypermethylation
BACKGROUND Neuroblastoma, a cancer derived from precursor cells of the sympathetic nervous system, is a major cause of childhood cancer related deaths. The single most important prognostic indicator of poor clinical outcome in this disease is genomic amplification of MYCN, a member of a family of oncogenic transcription factors. METHODOLOGY We applied MYCN chromatin immunoprecipitation to mic...
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Genes are often regulated in living cells by proteins called transcription factors (TFs) that bind directly to short segments of DNA in close proximity to specific genes. These binding sites have a conserved nucleotide appearance, which is called a motif. Several recent studies of transcriptional regulation require the reduction of a large collection of motifs into clusters based on the similar...
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Transcription factors (TFs) play crucial roles in regulating gene expression through interactions with specific DNA sequences. Recently, the sequence motif of almost 400 human TFs have been identified using high-throughput SELEX sequencing. However, there remain a large number of TFs (∼800) with no high-throughput-derived binding motifs. Computational methods capable of associating known motifs...
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Background: Exercise is one of the methods affecting cardiovascular adaptation, but its cellular and molecular pathways and mechanisms are unknown. T-Box Transcription Factor 5 (TBX5) gene seems to be one of the factors involved in regulating cardiac hypertrophy. Objective: The aim of this study was to investigate the effect of an 8-week exercise program with different intensities on the expre...
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ژورنال
عنوان ژورنال: Integrative Biology
سال: 2016
ISSN: 1757-9694,1757-9708
DOI: 10.1039/c6ib00079g